Safety Auxiliary Feedback Element for the Artificial Pancreas in Type 1 Diabetes

TitleSafety Auxiliary Feedback Element for the Artificial Pancreas in Type 1 Diabetes
Publication TypeJournal Article
Year of Publication2013
AuthorsRevert A, Garelli F, Picó J, De Battista H, Rossetti P, Vehí J, Bondia J
JournalBiomedical Engineering, IEEE Transactions on
Date PublishedAug
KeywordsAbsorption, Artificial, artificial organs, Artificial pancreas, Biological, Blood Glucose Self-Monitoring, closed loop systems, closed-loop glucose control, Computer Simulation, Computer-Assisted, Diabetes, Diabetes Mellitus, diseases, drug delivery systems, Drug Therapy, drugs, Equipment Safety, FDA-accepted UVA simulator, feedback, glucose control, glycemic control, Humans, hypoglycemia, insulin, insulin-on-board, medical control systems, Models, Pancreas, Physiological, postprandial period, Proposals, reference conditioning, Robustness, safety, safety auxiliary feedback element, sliding mode (SM), sliding mode reference conditioning, Sugar, two-step constrained control algorithms, Type 1, type 1 diabetes

The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the artificial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator.

Research Line: 
Control de sistemas y procesos biológicos
Control of biological processes and systems
Artificial pancreas
Páncreas artificial