Online adjustable linear parameter-varying controller for artificial pancreas systems

TitleOnline adjustable linear parameter-varying controller for artificial pancreas systems
Publication TypeJournal Article
Year of Publication2023
AuthorsBianchi FD, Sánchez-Peña RS, Garelli F
JournalBiomedical Signal Processing and Control
KeywordsArtificial pancreas, Diabetes type 1, insulin-on-board, LPV control

The purpose of this article is to present a non-hybrid fully closed-loop controller for the Artificial Pancreas (AP) problem focused on long-term clinical trials and home-use applications. It includes physical activity (PA) and unannounced meals. The controller is based on a robust gain-scheduled algorithm with a Linear Parameter-Varying (LPV) structure. It takes into account the time-varying dynamics of the problem by adapting itself in real-time according to measured glucose levels, and allows online fine-tuning during tests and periodic evaluations without the need of a controller redesign. The proposed fully parameterized LPV control adds several features to our previous results, accounts for the main perturbations of the AP problem and simplifies its implementation. To help in the parameter fine-tuning, a methodology based on clinical information is proposed. In-silico tests show that the achieved performance is similar or better than our previous Automatic Regulation of Glucose (ARG) algorithm, tested in two clinical trials, with the addition of the features mentioned before.

Research Line: 
Control de sistemas y procesos biológicos
Control of biological processes and systems
Artificial pancreas
Páncreas artificial