Automatic regulatory control in type 1 diabetes without carbohydrate counting

TítuloAutomatic regulatory control in type 1 diabetes without carbohydrate counting
Tipo de PublicaciónJournal Article
Año de Publicación2018
AutoresColmegna P, Garelli F, De Battista H, Sánchez-Peña R
JournalControl Engineering Practice
Volumen74
Páginas22 - 32
ISSN0967-0661
Resumen

A new approach to automatically regulate the glucose level in type 1 diabetes is presented in this work. This is the so-called Automatic Regulation of Glucose (ARG) algorithm, which is based on a switched Linear Quadratic Gaussian (LQG) inner controller, combined with an outer sliding mode safety loop with Insulin on Board (IOB) constraints. In silico and in vivo results without feedforward insulin boluses delivered at meal times indicate that safe blood glucose control can be achieved by the proposed controller. This controller is simple to migrate to well-known hardware platforms, and intuitive to tune using a priori clinical information.

DOI10.1016/j.conengprac.2018.02.003
Líneas de investigación: 
Teoría de Control
Control theory
Artificial pancreas
Páncreas artificial