Control of fed-batch bioreactors

TitleControl of fed-batch bioreactors
Publication TypeBook Chapter
Year of Publication2005
AuthorsPicó J, Picó-Marco E, Navarro JL, De Battista H
EditorAstolfi A
Book TitleNonlinear and Adaptive Control: Tools and Algorithms for the User
PublisherImperial College Press

This chapter addresses the control of microbial specic growth rate in fedbatch bioreactors. Practical constraints concerning the available signals and information on the process are dealt with. Then, for a large class of bioreactions, namely pure cultures with one limiting substrate and oxygen in excess, the control problem is regarded as a problem of coordinating control involving the invariance and attractivity of nontrivial sets in state space. Both monotonous and non-monotonous kinetic functions are dealt with. The dissolved oxygen signal can give valuable information about the cell culture, when the oxygen supply is in balance with the consumption. This is utilized for a probing feeding strategy, treated in chapter 1, part II.

Research Line: 
Control de sistemas y procesos biológicos
Control of biological processes and systems
Control and monitoring of bioprocesses
Control y monitoreo de bioprocesos